Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disorder characterized by a progressive loss of motor function. ALS affects upper motor neurons and lower motor neurons. As these motor neurons stop working, muscles also begin to atrophy; this can eventually lead to respiratory failure, which is often the cause of death in ALS patients. The pathophysiology of ALS is not completely understood, but similar to other neurodegenerative diseases like Alzheimer's disease it is characterized by clusters of dysfunctional proteins within neurons. In this video, I discuss ALS symptoms and pathophysiology.
Welcome to Neuroscientifically Challenged! All of the content for the site is collected on this home page, but if you're looking for specific types of content you can use the menu bar above. By clicking on Articles, you'll find links to blog articles on a variety of different neuroscience topics. The Know Your Brain link will take you to a listing of reference articles, each of which deals with a different part of the nervous system. Clicking on the 2-Minute Neuroscience Videos link will take you to an assortment of 2-minute videos that each teach you about a different aspect of neuroscience. And the Glossary contains a large selection of definitions for common neuroscience terms.